VDR is a gene that encodes a vitamin D receptor protein. This protein regulates calcium absorption as well as bone development. A variant of the gene (rs2228570 FokI polymorphism) is associated with lower bone mineral density in white prepubescent girls.
The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is controlled by the reciprocal and temporal pattern of on- and off occupancy of the VDRE by two components, and it is influenced by chromosomal location and binding preferences icloud for certain hormones. Microarray studies on human cells reveal that over 100 genes contain a VDRE. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.
A virtual data room (VDR) is an online repository for information and documents related to business, legal transactions or other proceedings that have restrictions on viewing and downloading. It utilizes central servers and an extranet connection that is an Internet connection that has restricted access to allow restricted access to log-in for specific intervals during which users can access the data and documents.
VDRs are most commonly used by investment banks and companies involved in mergers and acquisitions. They need to be able to communicate information in a clear manner with potential investors or buyers. The due diligence process can also require a large amount of information. Life science companies also make use of VDRs for everything from clinical trial results to HIPAA documentation for compliance.